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Howard P. Sard
Vice President of Organix Inc.

BIOGRAPHICAL SKETCH
EDUCATION

Research and Professional Experience

Professional Activities

Publications

• "(Trimethylsilyl)vinylketene, a stable vinylketene and reactive enophile in 4+2 cycloadditions," R. Danheiser and H. Sard, J. Org. Chem., 45, 4810, 1980.
• "Cyclohexenol annulation via the alkoxy-accelerated rearrangement of vinylcyclobutanes," R. Danheiser, C. Martinez-Davila and H. Sard, Tetrahedron, 37, 3943, 1981.
• "A 4+4 annulation approach to eight-membered carbocyclic compounds," R. Danheiser, S. Gee and H. Sard, J. Am. Chem. Soc., 104, 7670, 1982.
• "The regiochemical course of 2+2 cycloadditions of dichloroketene with vinyl- and alkynylsilanes," R. Danheiser and H. Sard, Tet. Letters, 23, 1983.
• "A novel route to 1-(N,N-dimethylamino)-2-butanol," H. Sard, R. Duffley and R. Razdan, Syn. Comm.,13, 813, 1983.
• "Improved procedure for the preparation of chiral 1,2-epoxybutanes: Total Synthesis of (S)-3'-hydroxy-Δ9-tetrahydrocannabinol (THC), a highly active metabolite of ?9-THC", H. Sard, R. Duffley, L. Robertson, and R. Razdan, Synthesis, 506, 1984.
• "The reaction between an azomethine and malonyl dichloride," H. Sard, P. Meltzer and R. Razdan, J. Het. Chem. 22, 257, 1985.
• "Ring closure of thiosemicarbazides with sulfuric acid-A structure correction," H. Sard, P. Meltzer and R. Razdan, J. Het. Chem., 22, 361, 1985.
• "Synthesis and Pharmacological Evaluation of Mercapto and Thioacetyl Analogs of Cannabidiol and Δ⁸-Tetrahydrocannabinol," D. Compton, P. Little, B. Martin, J. Saha, J. Gilman, H. Sard, and R. Razdan, Eur. J. Med. Chem., 24, 293, 1989.
• "Synthesis and Pharmacological Evaluation of Amino, Azido, and Nitrogen Mustard Analogues of 10-Substituted Cannabidiol and 11- or 12-Substituted Δ⁸-      Tetrahydrocannabinol," D. Compton, P. Little, B. Martin, J. Saha, J. Gilman, V. Jorapur, H. Sard, and R. Razdan, J. Med. Chem., 33, 1437, 1990.
• "An Unexpected Product During Synthesis of 3-Phenylisoquinoline: Improved Preparation of 4-Hydroxy-3-phenylisoquinoline" H. Sard, J. Het. Chem. 31, 1085, 1994.
• "Synthesis and Antiviral Activity of the Cyclopropano Homolog of 2,3-Didehydro-     2,3-dideoxythymidine" H. Sard, Nucleosides and Nucleotides 13, 2321, 1994.
• "The Synthesis and Pharmacological Evaluation of the Cannabinoid Antagonist SR 141716" A. Dutta, H. Sard, W. Ryan, R. Razdan, D. Compton, and B. Martin, Med. Chem. Res. 5, 54, 1994.
• "Cyclization of 3-Fluorophenol and 3,3-Dimethylacrylic acid: A Structure Correction" F. Shawcross and H. Sard J. Het. Chem., 32, 1393, 1995.
• "Preparation of 4,5-Disubstituted Pyrimidines: Ring Substitution of 5-Mesyloxymethylpyrimidines" H. Sard, M. Gonzalez, A. Mahdevan, and J. McKew J. Org. Chem. 65, 9261, 2000.
• "A General Method for C3 Reductive Alkylation of Indoles" A.Mahadevan, H. Sard, M. Gonzalez, and J. McKew Tetrahedron Letters 44, 4589, 2003. 
• “SAR of Psilocybin Analogs: Discovery of a Selective 5-HT2C Agonist” H. Sard, G. Kumaran, C. Morency, B. Roth, B. Toth, P. He, and L. Shuster Bioorg. Med. Chem. Lett. 15, 4555, 2005.
• “Inhibition of Cytosolic Phospholipase A2a: Hit to Lead Optimization” J. McKew, M. Foley, P. Thakker, M. Behnke, F. Lovering, F.-W. Sum, S. Tam, K. Wu, M. Shen, W. Zhang, M. Gonzalez, S. Liu, A. Mahadevan, H. Sard, S. Khor, J. Clark J. Med. Chem. 49, 135, 2006.

Books

1. Contributor to "Encyclopedia of Reagents for Organic Synthesis", L. Paquette, Editor, John Wiley and Sons, Ltd., Sussex, UK, 1995.

Patents

• "Use of Spiperone Derivatives as Immunosuppressant Agents," R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and H. Sard, U. S. Patent No. 5,574,041 (1996).
• "Buspirone as a Systemic Immunosuppressant," R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and H. Sard, U. S. Patent No. 5,484,788 (1996).
• "Use of Spiperone or Spiperone Derivatives as Immunosuppressant Agents," R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and H. Sard, U. S. Patent No. 5,693,645 (1997).
• "Topical Application of Spiperone or Derivatives Thereof forTreatment of Pathological Conditions Associated with Immune Responses" R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and  H. Sard, U. S. Patent No. 5,703,088 (1997).
• "Indole Compounds Useful as Serotonin Selective Agents" H. Sard, L. Shuster, B. Roth, C. Morency, G. Kumaran, L. Xu, U.S. 7,655,691, issued February 2, 2010.
• "Indole Compounds and Methods of Use Thereof" H. Sard, Y. Zhang, J. Li, L. Shuster, B. Roth, U.S. Patent Application No. 61/027825; filed February 11, 2008.

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