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Paul Blundell
Vice President of Organix Inc.

BIOGRAPHICAL SKETCH
EDUCATION

Research and Professional Experience

Awards

Professional Activities

Consultant

NIH, November 14, 1994: Division of Research Grants, Technology and Applied Sciences Review Section; Special Study Section W (5).

Publications

• "Acyl Derivatives of Hydroxamic Acids as a Source of Carbon Radicals", D. H. R. Barton, P. Blundell, J. Cs. Jaszberenyi. Tetrahedron Letters, 30, 2341, 1989.
• "Quantum Yields in the Photochemically Induced Radical Chemistry of Acyl Derivatives of Thiohydroxamic Acids", D. H. R. Barton, P. Blundell, J. Cs. Jaszberenyi. J. Am. Chem. Soc., 113, 6937, 1991.
• "The Invention of Radical Reactions. Part XXI. Simple Methods for the Radical Deoxygenation of Primary Alcohols", D. H. R. Barton, Paul Blundell, Joseph Dorchak, Doo Ok Jang and Joseph Cs. Jaszberenyi. Tetrahedron, 47, 8969, 1991.
• "The Invention of Radical Reactions. Part XXVIII. A New very Photolabile O-Acyl Thiohydroxamic Acid Derivative as Precursor of Carbon Radicals", D. H. R. Barton, P. Blundell, J. Cs. Jaszberenyi. Tetrahedron, 48, 7121, 1992.
• "Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation", P. Blundell, Ashit K. Ganguly, Viyyoor M. Girijavallabhan. Synlett, 263, 1994.
• "Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation", P. Blundell, Ashit K. Ganguly, Viyyoor M. Girijavallabhan. 24th National Medicinal Chemistry Symposium, Salt Lake City, U.S.A., Abstract No. 58, June 21-24, 1994.
• "Design and synthesis of technepine: A 99mTechnetium Probe which Labels the Dopamine Transporter", Peter C. Meltzer, Paul Blundell, Alun G. Jones, Ashfaq Mahmood, Robert E. Zimmerman, Basem Garada, B. Leonard Holman, Alan Davison, and Bertha K. Madras. CPDD, abstract 1996.
• "Technepine: A High-Affinity 99mTechnetium Probe to Label the Dopamine Transporter in Brain by SPECT Imaging", Bertha K. Madras, Alun G. Jones, Ashfaq Mahmood, Robert E. Zimmerman, Basem Garada, B. Leonard Holman, Alan Davison, Paul Blundell, and Peter C. Meltzer. Synapse, 22, 239-246, 1996.
• "Nitrogen-Based Drugs Are Not Essential for Blockade of Monoamine Transporters", Bertha K. Madras, Zdenek B. Pristupa, Hyman B. Niznik, Anna Y. Liang, Paul Blundell, Mario D. Gonzalez, and Peter C. Meltzer. Synapse, 24, 340-348, 1996.
• "A 99mTechnetium SPECT imaging agent which targets the dopamine transporter in primate brain", P. C. Meltzer, P. Blundell, A. G. Jones, A. Mahmood, B. Garada, R. E Zimmerman, A. Davison, B. L. Holman, B. K. Madras, J. Med. Chem., 40, 1835-1844, 1997.
• "2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: Potent Non-Nitrogen Inhibitors of Monoamine Transporters", P. C. Meltzer, A. Y. Liang, P. Blundell, M. D. Gonzalez, Z. Chen, C. George, and B. K. Madras, J. Med. Chem., 40, 2661-2673, 1997
• "A Ring Opening Rearrangement Reaction of 6b-Hydroxtropinone", Z. Chen, M. D. Gonzalez, P. Blundell, P. C. Meltzer, Tet. Lett., 38, 6823-6824, 1997.
• "Structure Activity Relationships of Inhibition of the Dopamine Transporter by 3-Arylbicyclo[3.2.1]octanes", P. C. Meltzer, P. Blundell, and B. K. Madras, Med. Chem. Res., 8, 12-34, 1998.
• "Bicyclo[3.2.1]octanes: Synthesis and Inhibition of Binding at the Dopamine and Serotonin Transporters", P. C. Meltzer, P. Blundell, Z. Chen, Y. Yong, and B. K. Madras, Bioorg. & Med. Chem. Lett., 9, 857-862, 1999.
• "3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes Inhibit WIN 35,428 Binding and Selectively at the Dopamine Transporter", P. C. Meltzer, P. Blundell, H. Huang, S. Liu, Y. F. Yong, and B. K. Madras, Bioorganic & Medicinal Chemistry, 8, 581-590, 2000.
• "2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters", P. C. Meltzer, P. Blundell, Y. F. Yong, Z. Chen, C. George, M. D. Gonzalez, and B. K. Madras, J. Med. Chem., 43, 2982-2991, 2000.
• "A tropane horse I. Design and synthesis of a dopamine sparing antagonist", P. C. Meltzer, P. Blundell, S. Liu, H. Blanchette and B. K. Madras, Drug and Alcohol Dependence, 63, 414, 2001.
• "A tropane horse II. O-1893 interferes with cocaine binding but permits dopamine transport: a cocaine antagonist strategy?" B. K. Madras, P. Blundell, S. Liu and P. C. Meltzer, Drug and Alcohol Dependence, 63, 378, 2001.
• "Synthesis of 6- and 7-hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters", P. C. Meltzer, B. Wang, Z. Chen, P. Blundell, M. Jayaraman, M. D. Gonzalez, C. George, and B. K. Madras, J. Med. Chem., 44, 2619-2635, 2001.
• "Synthesis and Antifungal Activity of the 2,2,5-Tetrahydrofuran Regioisomers of SCH 51048", Raymond G. Lovey, Anil K. Saksena, Viyyoor M. Girijavallabhan, P. Blundell, Henry Guzik, David Loebenberg, Raulo M. Parmegiani and Anthony Cacciapuoti , Bioorganic & Medicinal Chemistry Letters, 12, 1739-1742, 2002.
• "Non-amines: A generalization to methylphenidate and indatraline". P. C. Meltzer, P. Blundell, and B. K. Madras, Drug and Alcohol Dependence", 60, S118:441, 2002.
• " Design and synthesis of an irreversible dopamine-sparing cocaine antagonist" P. C. Meltzer, S. Liu, H. S. Blanchette, P. Blundell, and B. K. Madras. Bioorg. & Med. Chem. 10, 3583, 2002.
• "Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate". P. C. Meltzer, P. Wang, P. Blundell, and B. K. Madras. J. Med. Chem. 46, 1538, 2003.
• "A Second Generation 99mTechnetium SPECT Agent That Provides In Vivo Images of the Dopamine Transporter in Primate Brain" P. C. Meltzer, P. Blundell, T. Zona, L. Yang, H. Huang, A. A. Bonab, E. Livni, A. Fischman and B. K. Madras. J. Med. Chem. 46, 3483, 2003.

Patents

• "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Z. Chen, USP 5,948,933.
• "Dopamine Transporter Imaging Agent", P. C. Meltzer, B. K. Madras, A. G. Jones, A. Mahmood, A. Davison, P. Blundell, USP 6,171,576.
• "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Z. Chen, USP 6,353,105.
• "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Z. Chen, US Patent 6,417,221.
• "Compounds with High Monoamine Transporter Affinity", P. C. Meltzer, B. K. Madras, P. Blundell, P. Wang, USP 6,525,206.
• "Dopamine Transporter Imaging Agent", P. C. Meltzer, P. Blundell, B. K. Madras, A. J. Fischman, A.G. Jones, Mahmood, A. USP 6,548,041.
• "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Chen, Zhengming, USP 6,670,375.
• "Compounds with High Monoamine Transporter Affinity", P. C. Meltzer, B. K. Madras, P. Blundell, P. Wang, USP 7,026,516.
• "Boat Tropanes", P. C. Meltzer, P. Blundell, B. K. Madras, USP 7,105,678.
• "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, USP 7,199,132.
• "Therapeutic Tropane Compounds", P. C. Meltzer, B. K. Madras, P. Blundell, S. Liu USP 7,439,264.
• "Tropane Compounds", P. Blundell, P. C. Meltzer, B. K. Madras, USP 7,476,740.

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