New at Organix

NEWS

• Organix was an exhibitor at the Massachusetts CRO/CMO Symposium that was held in the Boston Marriott in Newton on February 25, 2013. The event demonstrated how drug development is accelerated through CRO partnerships. Organix met many new clients and we look forward to helping our new contacts move their projects forward rapidly and effectively! For more information about Organix or to make an appointment to speak with an Organix team member please contact Richard Gabriel, Director, Business Development.


• Organix welcomes Richard Gabriel, BS, MBA as Director, Business Development. Richard has considerable experience in providing outsourcing solutions to large, small and virtual pharma. He has established and managed discovery and cGMP facilities and instituted several joint ventures in chemistry and discovery fields. As a co-founder of Pharm-Eco Laboratories, Richard brings an extensive knowledge of Scale-up and Contract Synthesis and Medicinal Chemistry Services to Organix. We welcome Richard to our team.


• AND SIGN A CONTRACT...


Organix and Sharp Edge Labs have signed a contract to provide key intermediates to create general purpose immunosensors. Sharp Edge Labs is a provider of enabling technologies for the drug discovery industry and is pioneering a new class of biosensors developed at Carnegie Mellon University in the laboratories of Dr. Alan Waggoner and Dr. Marcel Bruchez. The Company's president and CEO, Dr.Scott Sneddon is the PI on an SBIR grant (1R43CA171427-01) awarded to fund the "Fluorogenic Molecular Proximity Detection Platform."

"I've known and worked with Dr. Paul Blundell of Organix over many years, first at Genzyme's Drug Discovery Group, and now at Sharp Edge, and I've always found Paul and his team to be great collaborators, and an extension of our own chemistry team," said Sneddon. "We're looking forward to developing key aspects of a new and exciting method of antibody detection that greatly simplifies the experiment, making it amenable to high-throughput, as well as increasing specificity," he added.

Organix will be responsible for a significant portion of the chemistry effort, with Sharp Edge contributing the biology portion of the project at its laboratories in Pittsburgh, PA. Dr. Blundell stated "It is great to see clients returning to Organix for services. This is a clear endorsement of the quality of chemistry and people at Organix and is always appreciated." Blundell added "Our team is excited to be involved in the development of Sharp Edge Lab's innovative Detection Platform."

• Jeffrey Hrkach of Bind Biosciences and coauthors (including MIT's Robert Langer) recently acknowledged the contribution Organix made to their cutting edge PSMA-Targeted Docetaxel Nanoparticle research. Organix was acknowledged for our work in synthesizing the monomer that was used in the synthesis of the PLA-PEG-ACUPA targeting polymer that was used in the reported study.


• Peter Meltzer, President & CEO of Organix, was recently interviewed by CEOCFO magazine. He took pleasure in describing Organix and the way Organix works hand-in-hand with its clients to provide exceptional chemistry service. He went on to discuss how Organix competes effectively with foreign competition and succeeds in securing projects. For a full description of the interview please visit the CEOCFO website or click on the link interview. For more information about how Organix can help your projects please contact Dr. Meltzer at info@organixinc.com


• Covidien, a client of Organix, recently presented a poster at the World Conference on Interventional Oncology (WCIO 2012, poster#53-page 67). Organix helped Covidien develop a microencapsulation based formulation of cisplatin that allows the sustained-release of the anti-cancer drug, cisplatin. This offers the potential for greater efficacy and reduced systemic toxicity. WCIO is a scientific forum designed to support Interventional Oncology (IO) therapies and is the perfect place to present such ground breaking discoveries. Organix is proud to be an enthusiastic collaborator in Covidien's cutting edge discoveries.


• Peter Meltzer, President & CEO of Organix, was the moderator at the MassBio CRO/CMO Drug Discovery & Outsourcing meeting held Thursday September 27, 2012 (link to the event here.) Participants included Dr. Bharat Lagu (Novartis), Dr. Nick Terrett (Ensemble Therapeutics), Dr. Curtis Keith (Harvard University), Carolyn Green (Altreaon Inc) and Dr. John Petersen (SynDevRx). The goal of this meeting was to discuss outsourcing discovery functions from early discovery chemistry to Phase 1 studies from the perspective of large pharma, small and virtual pharma and academia. Contact Dr. Meltzer at info@organixinc.com for additional information and to find out how Organix can help accelerate your project.


• Peter Meltzer, President & CEO of Organix, attended the annual Pharma ChemOutsourcing Meeting in Long Branch, New Jersey. He enjoyed participating in many discussions. In particular he was interested in the panel discussion on where the global trend in chemistry outsourcing is heading. As outsourcing costs overseas rise, companies are going to choose to stay within the US and reap the benefits of a mature US-CRO market. To find out where Dr. Meltzer thinks the global trend in chemistry outsourcing is heading please send him an email at info@organixinc.com


• Professor Alexandros Makriyannis recently visited Organix. He presented an overview of the latest advances to emerge from his laboratories in the cannabinoid field. Professor Makriyannis holds the George D. Behrakis Chair in Pharmaceutical Biotechnology and is Director of Northeastern University's Center for Drug Discovery. Professor Makriyannis is internationally recognized as a leader in the field of cannabinoids, their biological activity, and their modes of action. His research interests include investigation of cannabinergic drugs that modulate the central nervous system and the immune system. His group has recently made exciting advances in the discovery and development of potential pharmacotherapies that target cannabinoid receptors.



• Professor Makriyannis and Organix' Vice President, Anu Mahadevan


• Organix exhibited at the 2012 BioInternational Convention held in Boston in June. Organix met many prospective new clients and also reconnected with clients who have used our services previously. We look forward to helping our new contacts discover how Organix can help move their projects forward rapidly and effectively!



• Organix Booth at BioInternational 2012

• Navidea signs option agreement to license Parkinson’s imaging agent from Alseres. Altropane is a radiopharmaceutical used with Single-Photon Emission Computed Tomography (SPECT) imaging to identify the status of areas of the brains in patients suspected of having Parkinson’s disease, a nervous system disorder that leads to shaking known as tremors and difficulty in movement. The imaging agent works by binding to the dopamine transporter on nerve cells in the brain. Altropane was invented by a collaboration of scientists at Organix, Harvard Medical School, Massachusetts General Hospital, and Northeastern University, and licensed to Alseres. http://www.medcitynews.com/2012/01/navidea


• Boston Business Journal interviews Dr. Meltzer, CEO of Organix, on the state of CROs in the Boston area. http://www.bizjournals.com/boston/


• Galenea and Organix Announce Exclusive License Agreement for 5-HT2C Agonists for the Treatment of Obesity. http://www.biospace.com/news_story

New Publications

• "3-Substituted Pyrazole Analogs of the Cannabinoid Type 1 (CB1) Receptor Antagonist Rimonabant: Cannabinoid Agonist-Like Effects in Mice via Non-CB1, Non-CB2 Mechanism", Wiley, J. L.; Selley, D. E.; Wang, P.; Kottani, R.; Gadthula, S.; Mahadevan, A.; J. Pharmacol. Exper.Ther., 2012, 340(2), 433.

• "Δ⁸-Tetrahydrocannabivarin protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress and inflammatory response involving CB2 receptors ", Batkai, S.; Mukhopadhyay, P.; Horvath, B.; Rajesh, M.; Gao, R. Y.; Mahadevan, A.; Amere, M.; Battista, N.; Lichtman, A. H.; Gauson, L. A.; Maccarrone, M.; Pertwee, R. G.; Pacher, P.; Br. J. Pharmacol ., 2011, 6.

• "Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastrichemorrhages in mice ", Kinsey, S. G.; O’Neal, S. T.; Nomura, D. K.; Long, J. Z.; Mahadevan, A.; Cravatt, B. F.; Grider, J. R.; Lichtman, A. H.; J. Pharmacol. Exper.Ther ., 2011, 338(3), 795.

• "The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes", Purushotham, M.; Sheri, A.; Pham-Huu, D-P.; Madras, B. K.; Janowsky, A.; Meltzer, P.C. Bioorg. & Med. Chem. Lett., 2011, 21, 48.

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