Education

Institution	Degree	Year Conferred	Field of Study
University of Stirling, Scotland	BSc (Hons.)	1988	Chemistry
Texas A&M University/University of Stirling	PhD	1991	Organic Chemistry

Research and Professional Experience

1997-                   Vice-President and member of the Board of Directors of Organix Inc.

1994-1997            Group Leader at Organix Inc.

1993-1994            Research Scientist at Organix Inc.

1991-1993            Postdoctoral Fellow at Schering-Plough Research Institute

1988-1991            Texas A&M University, College Station. Res. Assist. to Prof. D.H.R. Barton

1986 - 1987          University of Stirling Scotland, Research Assistant

Awards

1988-1991            Schering Scholar, Texas A& M University.

1986                    Carnegie Scholarship, University of Stirling, Scotland.

Consultant

NIH, November 14, 1994: Division of Research Grants, Technology and Applied Sciences Review Section; Special Study Section W (5).

Publications

1.'Acyl Derivatives of Hydroxamic Acids as a Source of Carbon Radicals.', D. H. R. Barton, P. Blundell, J. Cs. Jaszberenyi Tetrahedron Letters, (1989), 30, 2341.

2.'Quantum Yields in the Photochemically Induced Radical Chemistry of Acyl Derivatives of Thiohydroxamic Acids.', D. H. R. Barton, P. Blundell, J. Cs. Jaszberenyi, J. Am. Chem. Soc. (1991), 113, 6937.

3.'The Invention of Radical Reactions. Part XXI. Simple Methods for the Radical Deoxygenation of Primary Alcohols.', D. H. R. Barton, P. Blundell, J. Dorchak, D-O. Jang and J. Cs. Jaszberenyi, Tetrahedron, (1991), 47, 8969.

4.'The Invention of Radical Reactions. Part XXVIII. A New very Photolabile O-Acyl Thiohydroxamic Acid Derivative as Precursor of Carbon Radicals.', D. H. R. Barton, P. Blundell, J. Cs. Jaszberenyi, Tetrahedron, (1992), 48, 7121.

5. 'Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation.', P. Blundell, A. K. Ganguly, V. M. Girijavallabhan, Synlett, (1994), 263.

6.'Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation.', P. Blundell, A. K. Ganguly, V. M. Girijavallabhan, 24th National Medicinal Chemistry Symposium, Salt Lake City, U.S.A., June 21-24, (1994), Abstract No. 58.

7.'Design and synthesis of technepine: A 99mTechnetium Probe which Labels the Dopamine Transporter' P. C. Meltzer, P. Blundell, A. G. Jones, A. Mahmood, R. E. Zimmerman, B. Garada, B. L. Holman, A. Davison, and B. K. Madras, CPDD, abstract (1996).

8.'Technepine: A High-Affinity 99mTechnetium Probe to Label the Dopamine Transporter in Brain by SPECT Imaging' B. K. Madras, A. G. Jones, A. Mahmood, R. E. Zimmerman, B. Garada, B. L. Holman, A. Davison, P. Blundell, and P. C. Meltzer, Synapse (1996), 22:239-246.

9.'Nitrogen-Based Drugs Are Not Essential for Blockade of Monoamine Transporters' B. K. Madras, Z. B. Pristupa, H. B. Niznik, A. Y. Liang, P. Blundell, M. D. Gonzalez, and P. C. Meltzer, Synapse (1996), 24:340-348.

10.'A Technetium-99m SPECT Imaging Agent Which Targets the Dopamine Transporter in Primate Brain' P. C. Meltzer, P. Blundell, A. G. Jones, A. Mahmood, B. Garada, R. E. Zimmerman, A. Davison, B. L. Holman, and B. K. Madras, Journal of Medicinal Chemistry, (1997), 40, 1835-1844.

11.'2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: Potent Non-Nitrogen Inhibitors of Monoamine Transporters' P. C. Meltzer, A. Y. Liang, P. Blundell, M. D. Gonzalez, Z. Chen, C. George, and B. K. Madras, Journal of Medicinal Chemistry, (1997), 40, 2661-2673.

12.'A Ring Opening Rearrangement Reaction of 6b-Hydroxytropinone' Z. Chen, M. D. Gonzalez, P. Blundell and P. C. Meltzer, Tetrahedron Letters, (1997), 38, 6823-6824.

13.'Structure Activity Relationships of Inhibition of the Dopamine Transporter by 3-Arylbicyclo[3.2.1]octanes' P. C. Meltzer, P. Blundell, B. K. Madras, Medicinal Chemistry Research, (1998), 8, 12-34.

14. 'Bicyclo[3.2.1]octanes: Synthesis and Inhibition of Binding at the Dopamine and Serotnin Transporters' P. C. Meltzer, P. Blundell, Z. Chen, Y. F. Yong, and B. K. Madras, Bioorganic & Medicinal Chemistry Letters, (1999), 9, 857-862.

15.'3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes Inhibit WIN 35,428 Binding and Selectively at the Dopamine Transporter' P. C. Meltzer, P. Blundell, H. Huang, S. Liu, Y. F. Yong, and B. K. Madras, Bioorganic & Medicinal Chemistry, (2000), 8, 581-590.

16.'2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: Potent Non-Nitrogen Inhibitors of Monoamine Transporters' P. C. Meltzer, P. Blundell, Y. F. Yong, Z. Chen, C. George, M. D. Gonzalez, and B. K. Madras, Journal of Medicinal Chemistry, (2000), 43, 2982-2991.

17.'Synthesis of 6- and 7- Hydroxy-8-azabicyclo[3.2.1]octanes and Their binding Affinity for the Dopamine and Serotonin Transporters' P. C. Meltzer, B. Wang, Z. Chen, P. Blundell, M. Jayaraman, M. D. Gonzalez, C. George, and B. K. Madras, Journal of Medicinal Chemistry, (2001), 44, 2619-2635.

18.'A tropane horse I. Design and synthesis of a dopamine sparing antagonist' P. C. Meltzer, P. Blundell, S. Liu, H. Blanchette, and B. K. Madras, Drug and Alcohol Dependence, (2001), 63, 414.

19.'A tropane horse II. O-1893 interferes with cocaine binding but permits dopamine transport: a cocaine antagonist strategy?' B. K. Madras, P. Blundell, S. Liu, and P. C. Meltzer, Drug and Alcohol Dependence, (2001), 63, 378.

20.'Synthesis and Antifungal Activity of the 2,2,5-Tetrahydrofuran Regioisomers of SCH 51048', R. G. Lovey, A. K. Saksena, V. M. Girijavallabhan, P. Blundell, H. Guzik, D. Loebenberg, R. M. Parmegiani and A. Cacciapuoti , Bioorganic & Medicinal Chemistry Letters, (2002), 12, 1739-1742.

21.'Design and Synthesis of an Irreversible Dopamine-Sparing Cocaine Antagonist' P. C. Meltzer, S. Liu, H. S. Blanchette, P. Blundell, and B. K. Madras, Bioorganic & Medicinal Chemistry, (2002), 10, 3583-3591.

22.'Non-amines: A Generalization to Methylphenidate and Indatraline'. P. C. Meltzer, P. Blundell, and B. K. Madras, Drug and Alcohol Dependence", (2002), 60, S118:441.

23.'Synthesis and Evaluation of Dopamine and Serotonin Transporter Inhibition by Oxacyclic and Carbacyclic Analogues of Methylphenidate' P. C. Meltzer, P. Wang, P. Blundell, and B. K. Madras, Journal of Medicinal Chemistry, (2003), 46, 1538-1545.

24.'A Second-Generation ^99mTechnetium Single Photon Emission Computed Tomography Agent That Provides in Vivo Images of the Dopamine Transporter in Primate Brain' P. C. Meltzer, P. Blundell, T. Zona, L. Yang, H. Huang, A. A. Bonab, E. Livni, A. Fischman, and B. K. Madras, Journal of Medicinal Chemistry, (2003), 46, 3483-3496.

Patents

1.'Tropane Analogs and Methods for Inhibition of Monoamine Transport', Peter C. Meltzer, Bertha K. Madras, Paul Blundell, and Zhengming Chen, US Patent #: 5,948,933 issue date: 9/7/99.

2.'Dopamine Transporter Imaging Agent' Peter C. Meltzer, Bertha K. Madras, Alan Davison, Paul Blundell, Ashfaq Mahmood, and Alun G. Jones, US Patent #: 6,171,576 issue date: 1/9/01.

3.'Tropane Analogs and Methods for Inhibition of Monoamine Transport', Peter C. Meltzer, Bertha K. Madras, Paul Blundell, and Zhengming Chen, US Patent #: 6,353,105 issue date: 3/5/02.

4.'Tropane Analogs and Methods for Inhibition of Monoamine Transport', Peter C. Meltzer, Bertha K. Madras, Paul Blundell, and Zhengming Chen, US Patent #: 6,417,221 issue date: 7/9/02.

5.'Compounds With High Monoamine Transporter Affinity', Peter C. Meltzer, Paul Blundell, Pinglang Wang and Bertha K. Madras, US Patent #: 6,525,206 issue date: 2/25/03.

6.'Dopamine Transporter Imaging Agents', Peter C. Meltzer, Paul Blundell, Bertha K. Madras, Alan J. Fischman, Alun G. Jones, and Ashfaq Mahmood, US Patent #: 6,548,041 issue date: 4/15/03.

7. 'Tropane Analogs and Methods for Inhibition of Monoamine Transport', Peter C. Meltzer, Bertha K. Madras, Paul Blundell, and Zhengming Chen, US Patent 6,670,375.

8. "Boat Tropanes", P. C. Meltzer, P. Blundell, and B. K. Madras, USP 7,105,678, 2006.

9. "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, P. Blundell, and B. K. Madras, USP 7,199,132, 2007.

10. "Therapeutic Compounds", P. C. Meltzer, B. K. Madras, P. Blundell, and Shanghao Lui, USP 7439264, 2008.

11. "Tropane Compounds", P. Blundell P. C. Meltzer, and B. K. Madras, USP 7,476,740, 2009.

Patent Applications

1.'Tropane Analogs and Methods for Inhibition of Monoamine Transport', Peter C. Meltzer, Bertha K. Madras, Paul Blundell, and Zhengming Chen, US Patent Application #: 20020010207 application date: 1/24/02.

2.'Boat Tropanes', Peter C. Meltzer, Paul Blundell, Bertha K. Madras, US Patent Application #: 20020131931 application date: 9/19/02.

3.'Tropane Analogs and Methods for Inhibition of Monoamine', Peter C. Meltzer, Bertha K. Madras, Paul Blundell, and Zhengming Chen, US Patent Application #: 20030069269 application date: 4/10/03.

4.'Tropane Analogs and Methods for Inhibition of Monoamine Transport', Peter C. Meltzer, Bertha K. Madras, and Paul Blundell, US Patent Application #: 20030105125 application date: 6/5/03.

5.'Therapeutic Tropane Compounds', Bertha K. Madras, Peter C. Meltzer, and Paul Blundell, US Patent Application #: 20030125352 application date: 7/3/03.