Education
| Institution |
Degree |
Year Conferred |
Field of Study |
University of Glasgow, U.K |
PhD |
1954 |
Organic Chemistry |
Indian Institute of Science, India. |
A.I.I.Sc. |
1951 |
Chemistry |
Indian Institute of Science, India. |
D.I.I.Sc |
1951 |
Chemical Engineering |
University of Delhi, India. |
BSc (Hons.) |
1948 |
Chemistry |
Research and Professional Experience
1986-2008 Co-founder, Chief Executive Officer and member of the Board of Directors of Organix Inc., a Massachusetts Research and Development Company.
1987-2008 Affiliate Professor, School of Basic Health Sciences, Virginia Commonwealth University
1970-1986 Co-founder, Principal Scientist, SISA Inc. Cambridge, MA.:
1964-1970 Senior Scientist, Arthur D. Little, Cambridge, MA.
1963-1964 Post-doctoral Fellowship, University of Michigan, Ann Arbor, MI.
1958-1963 Factory Manager, Glaxo Laboratories, Bombay, India:
1956-1958 Senior Scientist, Glaxo Laboratories, England. Research and Development.
1954-1956 Junior Scientific Officer, National Chemical Laboratory, India.
Professional Activities
1956- Member, Royal Institute of Chemistry, England.
1956- Member, Chemical Society, London, England.
1964- Member, American Chemical Society.
1985- Member, American Association for the Advancement of Science.
Invited Speaker
1969 CIBA Symposium, London.
1970 Gordon Conference, Medicinal Chemistry.
1970 Marijuana Symposium, Stockholm, Sweden.
1972 American Chemical Society, New Jersey.
1974,1977 National ACS Symposium.
1980 ASPET Symposium.
1982 Marijuana Symposium, Louisville, Kentucky (ASPET).
1983 Alfred Benzon Symposium 20, Copenhagen, Denmark.
Consultant
National Institute of Drug Abuse (NIDA)
National Cancer Institute (NCI)
Sarabhai Industries, India
Interviews
Radio: A New Side of Marijuana, for Men and molecules American Chemical Society.
Television: Therapeutic Potential of Marijuana, CBS News with Walter Croncite, 1970.
Other: Symposia, a Communication Service of the American Chemical Society, 1974.
Citations/Awards
American Men and Women in Science.
Who's Who in Technology Today, 1st and 2nd Editions.
Men of Achievement , 8th Edition, England.
Directory of World Researchers' 1980's Subjects, Japan.
Recipient Mechoulam Award, 2003 (Outstanding contributions in cannabinoid research)
Who's Who in America, 57th Ed. 2003
Patents
Over 57 U.S. and foreign patents in CNS drugs.
US Patent 5,847,128 ÒWater Soluble Derivatives of CannabinoidsÓ
US Patent 6,509,367 "Pyrazole cannabinoid agonist and antagonist".
US Patent 6,563,009 "Vasodilator cannabinoid analogs"
Book Chapters
"Progress in Organic Chemistry", Vol. 8 Butterworths, London, 1973.
"Advances in Drug Research", Academic Press, 1977.
"Handbook of Experimental Pharmacology", Springer-Verlag, 1977.
"The Total Synthesis of Natural Products", Vol. IV, John Wiley & Sons, 1981.
"Natural Products and Drug Development", Alfred Benzon Symposium 20, 1984.
"Cannabinoid Receptors", ed. R.Pertwee, Academic Press, London, 1995.
Selected Publications: (Over 200 publications in international scientific journals)
1. "Hashish: Oxidation of D8-Tetrahydrocannabinol (THC); Synthesis of D8-THC-1,2-Dione and 2-Hydroxy-D8-THC". H. Hodjat-Kashani, G. Lambert, R.P. Duffley and R.K. Razdan, Heterocycles 1986, 24, 1973.
2. "Structure-Activity Relationships in Cannabinoids," R.K. Razdan, Pharmacological Reviews 1986, 38, 75.
3. "Synthesis and Pharmacological evaluation of mercapto and thioacetyl anaiogues of cannabidiol and D8-tetrahydrocannabinol", D.R. Compton, P.J. Little, B.R. Martin, J.K. Saha, J. Gilman, H. Sard and R.K. Razdan, Eur. J. Med. Chem. 1989, 24, 293.
4. "An optically Active Terpenic Synthon for D9-cannabinoids: Synthesis of (-)-11-Hydroxy-D9-tetrahydrocannabinol (THC) and its 1',1'-Dimethylheptyl Analogue", C. Siegel, P.M. Gordon and R.K. Razdan, J. Org. Chem. 1989, 54, 5428.
5. "Synthesis and Pharmacological Evaluation of Amino, Azido, and Nitrogen Mustard Analogues of 10-substituted cannabidiol and 11- or 12- substituted D8-Tetrahydrocannabinol", D.R. Compton, P.J. Little, B.R. Martin, J.W. Gilman, J.K. Saha, V.S. Jorapur, H.P. Sard and R.K. Razdan, J. Med. Chem. 1990, 33, 1437.
6. "An Expedient and Efficient Synthesis of an Optically Active Terpene Synthon for D9-Cannabinoids", P.M. Gordon, C. Siegel and R.K. Razdan, Chem. Commun. 1991, 692.
7. Studies on the synthesis of (-)-11-Nor-9-carboxy-D9-tetrahydrocannabinol (THC) and related compounds: An Improved Oxidative Procedure", C. Siegel, P.M. Gordon, and R.K. Razdan, Synthesis 1991, 851.
8. "Behavioral, Biochemical and Molecular Modeling Evaluations of Cannabinoid Analogs", B.R. Martin, D.R. Compton, B.F. Thomas, W.R. Prescott, P.J. Little, R.K. Razdan, M.R. Johnson, L.S. Melvin, R. Mechoulam and S.J. Ward, Pharmacol. Biochem. Behav. 1991, 40, 471.
9. "Synthesis of Racemic and Optically Active D9-Tetrahydrocannabinol (THC) Metabolites", C. Siegel, P.M. Gordon, D.B. Uliss, G.R. Handrick, H.C. Dalzell and R.K. Razdan, J. Org. Chem. 1991, 56, 6865.
10. "Synthesis and Pharmacological Evaluation of Ether and Related Analogues of D8, D9-, and D9,11-Tetrahydrocannabinol", D.R. Compton, W.R. Prescott Jr., B.R. Martin, C. Siegel, P.M. Gordon and R.K. Razdan, J. Med. Chem. 1991, 34, 3310.
11. "Cannabinoid Structure-Activity Relationships: Correlation of Receptor Binding and in vivo Activities" D.R. Compton, K.C. Rice, B.R. Decosta, R.K. Razdan, L.S. Melvin, M.R. Johnson and B.R. Maring, J. Pharmacol. Exper. Ther. 1993, 265, 218.
12. "The Pharmacological Activity of Anandamide, A Putative Endogenous Cannabinoid, in Mice", P.B. Smith, D.R. Compton, S.P. Welch, R.K. Razdan, R. Mechoulam, and B.R. Martin, J. Pharmacol. Exper. Ther. 1994,270, 219.
13. "Synthesis of (R)- and (S)-4'-Acetoxyolivetol [5-(4-acetoxypentyl)-1,3-benzenediol]: Key Intermediates in the Synthesis of Tetrahydrocannibinol Derivatives", M. Singer, C. Siegel, P.M. Gordon, A.K. Dutta, R.K. Razdan, Synthesis 1994, 486.
14. "Evaluation of Cannabinoid Receptor Binding and in vivo Activities of Anandamide Analogs", I.B. Adams, W. Ryan, M. Singer, B.F. Thomas, D.R. Compton, R.K. Razdan, B.R. Martin, J. Pharmacol. Exp. Ther. 1995, 273, 1172.
15. "A Novel Class of Potent Tetrahydrocannabinols (THCs): 2'-yne-D8- and D9-THCs", W. Ryan, M. Singer, R.K. Razdan, D.R. Compton, B.R. Martin, Life Sci.. 1995, 56, 2013.
16. "Pharmacological And Behavioral Evalution Of Alkylated Anandamide Analogs", Adams, I. B.; Ryan, W.; Singer, M.; Razdan, R.K.; Compton, D. R.; Martin, B. R. Life Sci.. 1995, 56, 2041.
17. "Pharmacological Evaluation of Dimethylheptyl Analogs of ?9-THC: Reassesment of the Putative Three Point Cannabinoid-Receptor Interaction", Martin, B.R.; Compton, D.R.; Prescott, W.R.; Barret, R. L.; Razdan, R.K. Drug and Alcohol Dependence 1995, 37, 231.
18. "Charachterization of Anandamide and Fluoroanandamide induced Antinociception and Cross Tolerence to D9-THC after Intrathecal Adminstration to Mice: Blockade of D9-THC-induced Antinociception",Welch, S. P.; Dunlow, L. D.; Patrick, G. S.; Razdan, R. K. J. Pharmacol. Exp. Ther. 1995, 273, 1235.
19. "The Synthesis and Pharmacological Evaluation of the Cannabinoid Antagonist SR14176A", Dutta, A. K.; Sard, H.; Ryan, W.; Razdan, R. K.; Compton, D. R.; Martin, B. R. Med. Chem.Res. 1995, 5, 54.
20. "Structure-Activity Analysis of Anandamide Analogs: Relationship to a Cannabinoid Pharmacophore", Thomas, B. F.; Adams, I. B.; Mascarella, S. W.; Martin, B. R.; Razdan, R. K. J. Med. Chem. 1996, 39, 471.
21. "Agonist-antagonist characterization of 6'-cyanohex-2'-yne-D8-tetrahydrocannabinol in two isolated tissue preparations", Pertwee, R. G.; Fernando, S. R.; Griffin, G.; Ryan, W.; Razdan, R. K.; Compton, D. R.; Martin, B. R. Eur. J. Pharmacol. 1996, 315, 195.
22. "Evalution of Agonist-Antagonist Properties of Nitrogen Mustard and Cyano Derivatives of D8-Tetrahydrocannabinol", Wiley, J. L.; Compton, D. R.; Gordon, P. M.; Siegel, C.; Singer, M.; Dutta, A. K.; Lichtman, A. H.; Balster, R. L.; Razdan, R. K.; Martin, B. R. Neuropharmacol. 1996, 35, 1793.
23. "Synthesis and Pharmacology of (R)- and-(S)-4'-Hydroxy-D8-Tetrahydrocanabinnols (THCs)", Singer, M.; Dutta, A. K.; Compton, D. R.; Martin, B. R.; Razdan, R. K. Eur. J. Med. Chem. 1997, 32, 165.
24. "Synthesis, Pharmacology and Molecular Modeling of Novel 4-Alkyloxy Indole Derivatives Related to Cannabimimetic Aminoalkyl Indoles (AAIs)", Dutta, A. K.; Ryan, W.; Thomas, B. F.; Singer, M.; Compton, D. R.; Martin, B. R.; Razdan, R. K. Bioorg. Med. Chem. 1997, 5, 1591.
25. "Potent Anandamide Analogs: The Effect of Changing the Length and Branching of the End Pentyl Chain", Ryan, W. J.; Banner, W. K.; Wiley, J. L.; Martin, B. R.; Razdan, R. K. J. Med. Chem.. 1997, in Press.
26. "Evaluation of Cannabimimetic Discriminative Stimulus Effects of Anandamide and Methylated Fluoroanandamide in Rhesus Monkeys", Wiley, J. L.; Golden, K. M.; Ryan, W. J.; Balster, R. L.; Razdan, R. K.; Martin, B. R. Pharmacol. Biochem. Behav. 1997, 58, 1139.
27. "Synthesis of (+)- and (-)-2-Methylarachidonyl-2'-Fluoroethylamide (O-689)", Ryan, W. J.; Banner, W. K.; Crocker, P. C.; Martin, B. R.; Razdan, R. K. Bioorg. Med. Chem. Lett.. 1997, 7, 2669.
28. Total Synthesis of Methyl 14-Hydroxy-(all-cis)-5,8,11,-Tetradecatrienoate: A Useful Intermediate For the Synthesis of Arachidonic Acid Analogues, Han, L. and Razdan, R. K. Tetrahedron Lett.. 1998, 39, 771.
29. Potent Cyano and Carboxamido Side-Chain Analogues of 1',1'-Dimethyl-D8-Tetrahydrocannabinol: Singer, M.; Ryan, W. J.; Saha, B.; Martin, B. R.; Razdan, R. K. J. Med.Chem. 1998, 41, 4400.
30. "Comparision of Cannabinoid binding sites in guinea-pig forebrain and small intestine" Ross, R. A.; Brockie, H. C.; Fernando, S. R.; Saha, B.; Razdan, R. K.; Pertwee, R. G. Br.J. Pharmacol. 1998, 125, 1345.
31. "Anandamide, an Endogenous Cannabinoid, Has a very low Physical Dependence Potential", Aceto, M. D.; Scates, S. M.; Razdan, R. K.; Martin, B. R. J. Pharm. Exp. Ther. 1998, 287, 598.
32. "Evaluation of Cannabimimetic effects of structural analogs of anandamide in rats", Wiley, J. L.; Ryan, W. J.; Razdan, R. K.; Martin, B. R. Eur. J. Pharmacol. 1998, 355, 113.
33. "Total Synthesis of 2-Arachidonylglycerol (2-Ara-Gl)", Han, L. and Razdan, R. K. Tetrahedron Lett. 1999, 40, 1631.
34. "Unique Analogues of Anandamide: Arachidonyl Ethers and Carbamates and Norarachidonyl Carbamates and Ureas", Ng, E. W.; Aung, M. M.; Abood, M. E.; Martin, B. R.; Razdan, R. K. J. Med. Chem. 1999, 42, 1975.
35. "An Investigation into the structural determinants of cannabinoid receptor ligand efficacy", Griffin, G.; Wray, E. J.; Rorrer, W. K.; Crocker, P. J.; Saha, B.; Razdan, R. K.; Martin, B. R.; Abood, M. E. Br.J. Pharmacol. 1999, 126, 1575.
36. "Manipulation of the Tetrahydrocannabinol Side Chain Delineates Agonists, Partial Agonists, and Antagonists", Martin, B. R.; Jefferson, R.; Winckler, R.; Wiley, J. L.; Huffman, J. W.; Crocker, P. J.; Saha, B.; Razdan, R. K. J. Pharm. Exp. Ther. 1999, 290, 1065.
37. "Discovery and Characterization of Endogenous Cannabinoids", Martin, B. R.; Mechoulam, R.; Razdan, R. K. Life Sci. 1999, 65, 573.
38. "Development of Agonists, Partial Agonists and Antagonists in the D8- Tetrahydrocannabinol Series", Crocker, P. J.;Saha, B.; Ryan, W. J.; Wiley, J. L.; Martin, B. R.; Ross, R. A.; Perwee, R. G.; Razdan, R. K.Tetrahedron, 1999, 55, 13907.
39. "Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-D8-Tetrahydrocannabinol at cannabinoid receptors", Ross, R. A.; Gibson, T. M.; Stevenson, L. A.; Saha, B.; Crocker, P.; Razdan, R. K.; Pertwee, R. G. Br. J. Pharmacol. 1999, 128, 735.
40. "Cannabinoid induced mesentric vasodilation through an endothelial site distinct from CB1 or CB2 receptors", Zolton, J.; Wagner, J. A.; Varga, K.; lake, K. D.; Compton, D. R.; Martin, B. R.; Zimmer, A. M.; Bonner, T. I.; Brickley, N. E.; Mezey, E.; Razdan, R. K.; Zimmer, A.; Kunos, G. Proc. Natl. Acad. Sci. USA, 1999, 96, 14136.
41. "QSAR Analysis of D8-THC Analogues: Relationship of Side-Chain Conformation to Cannabinoid Receptor Affinity and Pharmacological Potency", Keimowitz, A. R.; Martin, B. R.; Razdan, R. K.; Crocker, P. J.; Mascarella, S. W.; Thomas, B. F. J. Med. Chem. 2000, 43, 59.
42. "Cardiovascular Effects of 2-Arachidonyl Glycerol in Anesthetized Mice", Zolton, J.; Wagner, J. A.; Goparaju, S. K.; Wang, L.; Razdan, R. K.; Sugiura, T.; Zimmer, A. M.; Bonner, T. I.; Zimmer, A.; Kunos, G. Hypertension, 2000, 35, 679.
43. "Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice: Evidence for Non-CB1, and Non-CB2 Receptor-Mediated Actions of Ananadamide in Mouse Brain", DiMarzo, V.; Breivogel, C. S.; Tao, Q.; Bridgen, D. T.; Razdan, R. K.; Zimmer, A. M.; Zimmer, A.; Martin, B. R. J. Neurochem. 2000, 75, 2434-2444.
44. "The Synthesis of N-Vanillyl-arachidonoyl-amide (Arvanil) and its Analogs: An Improved Procedure for the Synthesis of the Key Synthon Methyl 14-Hydroxy-(all-cis)-5,8,11,-Tetradecatrienonate", Dasse, O.; Mahadevan, A.; Han, L.; Martin, B. R.; DiMarzo, V.; Razdan, R. K. Tetrahedron, 2000, 56, 9195-9202.
45. "Highly Selective CB1 Cannabinoid Receptor ligands and Novel CB1/VR1 Vanilloid Receptor "Hybrid Ligands", DiMarzo, V.; Bisogno, T.; DePetrocellis, L.; Brandi, I.; Jefferson, R. G.; Winckler, R. L.; Davis, J. B.; Dasse, O.; Mahadevan, A.; Razdan, R. K.; Martin, B. R. Biochem. Biophys. Res. Commun. 2001, 281, 444-451.
46. "Novel Pyrazole Cannabinoids: Insights into CB1 Receptor Recognition and Activation", Wiley, J. L.; Jefferson, R. G.; Grier, M. C.; Mahadevan, A.;. Razdan, R. K.; Martin, B. R. J. Pharmacol. Exp. Ther. 2001, 296, 1013-1022.
47. "Assessment of structural commonality between tetrahydrocannabinol and anandamide", Martin, B. R.;.Jefferson, R. G.; Winckler, R.; Wiley, J. L.; Thomas, B. R.; Crocker, P. J.; Williams, W.; Razdan, R. K. Eur. J. Pharmacol. 2002, 435, 35-42.
48. "A Structure/Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid", DiMarzo, V.; Griffin, G.; DePetrocellis, L.; Brandi, I.; Bisogno, T.; Williams, W.; Grier, M. C.; Kulasegram, S.; Mahadevan, A.; Razdan, R. K.; Martin, B. R. J. Pharmacol. Expt. Ther. 2002, 300, 984-991.
49. "Resorcinol Derivatives: A Novel Template for the Development of Cannabinoid CB1/CB2 and CB2-Selective Agonists", Wiley, J. L.; Beletskaya, I. D.; Ng, E. D.; Zongmin, D.; Crocker, P.J.; Mahadevan, A.; Razdan, R. K.; Martin, B. R. J. Pharmacol. Expt. Ther. 2002, 301 679-689.
50. "Recent advances in the synthesis of endocannabinoid related ligands", Razdan, R. K. and Mahadevan, A. Chem. Phys. Lipids, 2002, 121/1-2, 21-33.
51. "SR-141716A-induced stimulation of locomotor activity; A Structure-activity relationship study", Bass, C. E.; Griffin, G.; Grier, M.; Mahadevan, A.; Razdan, R. K.; Martin, B. R. Pharmacol. Biochem. Behav. 2002, 74, 31-40.
52. "Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor", Offertaler, L.; Mo, F-M.; Batkai, S.; Liu, J.; Begg, M.; Razdan, R. K.; Martin, B. R.; Bukoski, R. D.; Kunos, G. Mol. Pharm. 2003, 63, 699-705.
53. "A novel methodology for the synthesis of 1-desoxy-D8-tetrahydrocannabinol (THC) analogues", Sun, H.; Mahadevan, A.; and Razdan, R. K. Tetrahedron Lett. 2004, 45, 615-617.
54. "A Comprison of the Discriminative Stimulus Effects D9-Tetrahydrocannabinol and O-1812, a Potent and Metabolically Stable Anandamide Analog in Rats", Wiley, J. L.; La Vecchia, K. L.; Karp, N. E.; Kulasegram, S.; Mahadevan, A.; Razdan, R. K.; Martin, B. R. Experimental and Clinical Psychopharmacology, 2004, 12, 173-179.
55. "6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist", Thomas, A.; Ross, R. A.; Saha, B.; Mahadevan, A.; Razdan, R. K.; Pertwee, R. G. Eur. J. Pharmacol. 2004, 487, 213-221.
56. "A synthetic route to anandamide analogues carrying a substituent at the terminal carbon and an acetylene group in the end pentyl chain", Altundas, R.; Mahadevan, A.; Razdan, R. K. Tetrahedron Lett. 2004, 45, 5449-5451.
57. "Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by anlogues of 2-arachidonylglycerol", Ghafouri, N.; Tiger, G.; Razdan, R. K.; Mahadevan, A.; Pertwee, R. G.; Martin, B. R.; Fowler, C. J. Br. J. Pharmacol. 2004, 143, 774-784.
58. "Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2Õ-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide", Kaplan, B. L. F.; Ouyang, Y.; Herring, A.; Yea, S. S.; Razdan, R.; Kaminski, N. E. Toxicol. Appl. Pharmacol. 2005, 205, 107-115.
59. "Task specificity of cross-tolerence between D9-tetrahydrocannabinol and anandamide analogs in mice", Wiley, J. L.; Smith, F. L.; Razdan, R. K.; Dewey, W. L. Eur. J. Pharmacol. 2005, 510, 59-68.
60. "Synthesis of novel 5-substituted pyrazole derivatives as cannabinoid antagonists", Alekseeva, O. O.; Mahadevan, A.; Wiley, J. L.; Martin, B. R.; Razdan. R. K. Tetrahedron Lett. 2005, 46, 2159-2161.
61. "CB1 cannabinoid receptor-mediated modulation of food intake in mice", Wiley, J. L.; Burston, J. J.; Leggett, D. C.; Alekseeva, O. O.; Razdan, R. K.; Mahadevan, A.; Martin, B. R. Br. J. Pharmacol. 2005, 145, 293-300.
62. "New Potent and Selective Inhibitors of Anandamide Re-Uptake with Anti-Spastic Activity in a Mouse Model of Multiple Sclerosis", Ligresti, A.; Cascio, M. G.; Pryce, G.; Kulasegram, S.; Beletskaya, I.; De Petrocellis, L.; Saha, B.; Mahadevan, A.; Visintin, C.; Wiley, J. L.; Baker, D.; Martin, B. R.; Razdan, R. K.; Di Marzo, V. Br. J. Pharmacol. 2006, 147, 83-91.
63. "Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonylglycerol with monoglycerol lipase and fatty acid amide hydrolase", Vandevoorde, S.; Saha, B.; Mahadevan, A.; Razdan, R. K.; Perwee, R. G.; Martin, B. R.; Fowler, C. J. Biochem. Biophys. Res. Commun. 2005, 337, 104-109.
64. "Novel compounds that interact with both leukotriene BLT and vanilloid TRPV1 receptors", McHugh, D.; McMaster, R. S.; Pertwee, R. G.; Roy, S.; Mahadevan, A.; Razdan, R. K.; Ross, R. A. J. Pharmacol. Expt. Ther. 2005, in Press.