Vice President of Organix
Education
Institution |
Degree |
Year Conferred |
Field of Study |
University of
Madras |
BSc |
1987 |
Chemistry |
IIT, Madras |
MSc |
1989 |
Chemistry |
Purdue University |
PhD |
1994 |
Organic Chemistry |
| Florida State University | Postdoctoral | 1995-1996 | Organic Chemistry |
Research and Professional Experience
2005 - Vice-President and member of the Board of Directors of Organix Inc., a Massachusetts Research and Development Company
2002 - 2004 Group Leader, Organix, Inc.
1997 - 2001 Research Scientist, Research Associate, Organix, Inc.
Awards
University Medal, University of Madras; BSc
Merit Scholarship; MS IIT Madras (1987 - 1989)
Mobil Fellowship, IIT Madras (summer 1990)
Publications
1. "A Mild and Convenient Synthesis of Functionalized Methyl Triflones and Vinyl Triflones", A. Mahadevan, P. L. Fuchs, Tetrahedron Lett. 1994, 35, 6025.
2. "Silver Fluoroborate-Promoted Sulfur Alkylation of β-Thioglycosides", A. Mahadevan, C. Li, P. L. Fuchs, Synth. Commun. 1994, 24(21), 3099.
3. "Synthesis and Pharmacological Evaluation of Vinyl Sulfone Based Anticancer Drugs", C. Li, A. Mahadevan, A. Arasappan, J. Philips, R. Merriman, L. Tanzer, P. L. Fuchs, Bioorg. Med. Chem. Lett. 1994, 4, 1585.
4. "Facile Synthesis of Allyl, γ-Iodoallyl, and Cyclopropyl Triflones via Radical-Mediated Atom-Transfer Addition of Iodomethyl Triflone to Olefins and Acetylenes", A. Mahadevan, P. L. Fuchs, J. Am. Chem. Soc. 1995, 117, 3272.
5. "Stereo- and Regiospecific Syntheses of α- and β-Substituted Vinyl and Dienyl Triflones via the Stille Reaction", J. S. Xiang, A. Mahadevan, P. L. Fuchs, J. Am. Chem. Soc. 1996, 118, 4284.
6. "Novel Cannabinol Probes for CB1 and CB2 Cannabinoid Receptors", A. Mahadevan, C. Siegel, B. R. Martin, M. E. Abood, I. Beletskaya, R. K. Razdan, J. Med. Chem. 2000, 43, 3778.
7. "Cannabinoid Properties of Methylfluorophosphonate Analogs", B. R. Martin, I. Beletskaya, G. Patrick, R. Jefferson, R. Winckler, D. Deutsch, V. DiMarzo, O. Dasse, A. Mahadevan, R. K. Razdan, J. Pharmacol. Exp. Ther. 2000, 294, 1209.
8. "The Synthesis of N-Vinillyl-arachidonyl-amide (Arvanil) and its Analogs: An Improved Procedure for the Synthesis of the key Synthon Methyl 14-hydroxy-(all-cis)-5,8,11-Tetradecatrienoate", O. Dasse, A. Mahadevan, L. Han, B. R. Martin, V. DiMarzo, R. K. Razdan, Tetrahedron 2000, 56, 9195.
9. "Preparation of 4,5-Disubstituted Pyrimidines: Ring Substitution of 5-Mesyloxymethylpyrimidines", H. Sard, M. D. Gonzalez, A. Mahadevan, J. McKew, J. Org. Chem. 2000, 65, 9261.
10. "Novel Pyrazole Cannabinoids: Insights into CB1 Receptor Recognition and Activation", J. L. Wiley, R. G. Jefferson, M. C. Grier, A. Mahadevan, R. K. Razdan, B. R. Martin, J. Pharmacol. Exper. Ther. 2001, 296, 1013.
11. "Highly Selective CB1 Cannabinoid Receptor Ligands and Novel CB1/VR1 Vanilloid Receptor “Hybrid” Ligands," V. DiMarzo, T. Bisogno, L. De Petocellis, I. Brandi, R. L. Jefferson, R. L. Winckler, J. B. Davis, O. Dasse, A. Mahadevan, R. K. Razdan, B. R. Martin, Biochem. Biophys. Res. Commun. 2001, 281, 444.
12. "A Structure Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid", V. DiMarzo, G. Griffin, L. De Petrocellis, I. Brandi, T. Bisogno, W. Williams, M. C. Grier, S. Kulasegram, A. Mahadevan, J. B. Davis, R. K. Razdan, B. R. Martin, J. Pharmacol. Exper. Ther. 2002, 300, 984.
13. "Resorcinol Derivatives: A Novel Template for the Development of Cannabinoid CB1/CB2 and CB2-Selective Agonists", J. L. Wiley, I. D. Beletskaya, E. W. Ng, D. Zongmin, P. J. Crocker, A. Mahadevan, R. K. Razdan, B. R. Martin, J. Pharmacol. Exper. Ther. 2002, 301, 679.
14. "Recent Advances in the Synthesis of Endocannabinoid Related Ligands", R. K. Razdan, A. Mahadevan, Chem. Phys. Lipids 2002, 121/1-2, 21.
15. "SR-141716A Induced Stimulation of Locomotor Activity; A Structure-Activity Relationship Study", C. E. Bass, G. Griffin, M. Grier, A. Mahadevan, R. K. Razdan, B. R. Martin, Pharmacol. Biochem. Behav. 2002, 74, 31-40.
16. "A General Method for C3 Reductive Alkylation of Indoles", A. Mahadevan, H. Sard, M. Gonzalez, J. C. McKew, Tetrahedron Lett. 2003, 44, 4589.
17. "A Novel Methodology for the Synthesis of 1-desoxy-Δ8-tetrahydrocannabinol (THC) analogues", H. Sun, A. Mahadevan, R. K. Razdan, Tetrahedron Lett. 2004, 45, 615.
18. "6”-Azidohex-2”-yne-cannabidiol: A Potent Neutral, Competitive Cannabinoid CB1 Receptor Antagonist", A. Thomas, R. A. Ross, B. Saha, A. Mahadevan, R. K. Razdan, R. G. Pertwee, Eur. J. Pharmacol. 2004, 487, 213.
19. "A Comparison of the Discriminative Stimulus Effects Δ9-Tetrahydrocannabinol and O-1812, a Potent and Metabolically Stable Anandamide Analog, in Rats", J. L. Wiley, K. L. LaVecchia, N. E. Karp, S. Kulasegaram, A. Mahadevan, R. K. Razdan, B. R. Martin, Experimental and Clinical Psychopharmacology 2004, 12, 173.
20. "A Synthetic Route to Anandamide Analogues Carrying a Substituent at the Terminal Carbon and an Acetylene Group in the End Pentyl Chain", R. Altundas, A. Mahadevan, R. K. Razdan, Tetrahedron Lett. 2004, 45, 5449.
21. "Inhibition of Monoacylglycerol Lipase and Fatty Acid Amide Hydrolase by Analogues of 2-Arachidonylglycerol", N. Ghafouri, G. Tiger, R. K. Razdan, A. Mahadevan, R. G. Pertwee, B. R. Martin, C. J. Fowler, Br. J. Pharmacol., 2004, 143,774. 2004, 143,774.
22. "Synthesis of novel 5-substituted pyrazole derivatives as cannabinoid antagonists", O. Alekseeva, A. Mahadevan, J. L. Wiley, B. R. Martin, R. K. Razdan, Tetrahedron Lett. 2005, 46, 2159.
23. "CB1 Cannabinoid Receptor-Mediated modulation of Food Intake in Mice", J. L. Wiley, J. J. Burston, D. C. Leggett, R. K. Razdan, A. Mahadevan, B. R. Martin, Br. J. Pharmacol. 2005, 145, 293.
24. "Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonylglycerol with monoglycerol lipase and fatty acid amide hydrolase", S. Vandevoorde, B. Saha, A. Mahadevan, R. K. Razdan, R. G. Pertwee, B. R. Martin, C. J. Fowler, Biochem. Biophys. Res. Commun. 2005, 337, 104.
25. "Further Advances in the Synthesis of Endocannabinoid-related Ligands", A. Mahadevan, R. K. Razdan, AAPS 2005, 07(02), E496.
26. "New Potent and Selective Inhibitors of Anandamide Re-Uptake with Anti-Spastic Activity in a Mouse Model of Multiple Sclerosis", A. Ligresti, M. G. Cascio, G. Pryce, S. Kulasegaram, I. Beletskaya, L. De Petrocellis, B. Saha, A. Mahadevan, C. Visintin, J. L. Wiley, D. Baker, B. R. Martin, R. K. Razdan, V. Di Marzo, Br. J. Pharmacol., 2006, 147,83.
27. "Inhibition of Cytosolic Phospholipase A2α: Hit to Lead Optimization", J. C. McKew, M. A. Foley, P. Thakker, M. L. Behnke, F. E. Lovering, F-W. Sum, S. Tam, K. Wu, M. W. H. Shen, W. Zhang, M. Gonzalez, S. Liu, A. Mahadevan, H. Sard, J. Med. Chem. 2006, 49, 135.
28. "Novel compounds that interact with both Leukotiene B4 receptors and vanilloid TRPV1 receptors", D. McHugh, R. S. McMaster, R. G. Pertwee, S. Roy, A. Mahadevan, R. K. Razdan, R. A. Ross, J. Pharmacol. Exper. Ther. 2006, 316, 955.
29. "Pharmacological Characterization of Novel Water-Soluble Cannabinoids", B. R. Martin, J. L. Wiley, I. Beletskaya, L. J. Sim-Selley, F. L. Smith, W. L. Dewey, J. Cottney, J. Adams, J. Baker, D. Hill, B. Saha, J. Zerkowski, A. Mahadevan, R. K. Razdan. J. Pharmacol. Exper. Ther. 2006, 318, 1230.
30. "The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids", P. J. Crocker, A. Mahadevan, J. L. Wiley, B. R. Martin, R. K. Razdan. Bioorg. Med. Chem. Lett. 2007, 17, 1504.
31. "Novel, potent THC/anandamide (hybrid) analogs", C. Bourne, S. Roy, J. L. Wiley, B. R. Martin, B. F. Thomas, A. Mahadevan, R. K. Razdan. Bioorg. Med. Chem. 2007, 15, 7850.
32. "Multiple pathways involved in the biosynthesis of anandamide", J. Liu, L. Wang, J. Harvey-White, B. X. Huang, H. Y. Kim, S. Luquet, R. D. Palmiter, G. Krystal, R. Rai, A. Mahadevan, R. K. Razdan, G. Kunos. Neuropharmacology. 2008, 54, 1, 1.
33. "Synthesis of 2-(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamidoethyl-d4 dihydrogen phosphate, tetra-deuterated pAEA", K. Cheng, B. Saha, A. Mahadevan, R. K. Razdan, G. Kunos, A. E. Jacobson, K. C. Rice. J. Label Compd. Radiopharm. 2008, 51, 389.
34. "Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonylglycerol", T. Bisogno, J. J. Burston, R. Rai, M. Allara, B. Saha, A. Mahadevan, R. K. Razdan, J. L. Wiley, V. Di Marzo Chem. Med. Chem In press
Patents:
1."Pyrazole Cannabinoid Agonist and Antagonist", B. R. Martin, R. K. Razdan, A. Mahadevan, USP 6,509,367 B1, 2003.
2. "Anti-spasticity of an eicosanoid analog", B. R. Martin, R. K. Razdan, A. Mahadevan, D. Baker, USP 6,800,770 B2, 2004.